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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNF168 All Species: 28.18
Human Site: S470 Identified Species: 62
UniProt: Q8IYW5 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IYW5 NP_689830.2 571 65020 S470 V P N R Q K G S P D E Y H L R
Chimpanzee Pan troglodytes XP_001164756 571 65044 S470 V P N R Q K G S P D E Y H L R
Rhesus Macaque Macaca mulatta XP_001098468 146 16847 S53 V E A E R R A S E E E E N K A
Dog Lupus familis XP_545152 570 65205 S469 K P N R Q K G S P D E Y Q L R
Cat Felis silvestris
Mouse Mus musculus Q80XJ2 565 64761 S469 V P N R Q K G S P D Q Y Q L R
Rat Rattus norvegicus B2RYR0 564 64386 S469 V P N R Q K G S P D Q Y Q L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519147 409 45328 L316 G S P D E Y L L R T K P P A S
Chicken Gallus gallus XP_001233498 605 68577 S503 L L N R Q K G S P D E Y L L R
Frog Xenopus laevis Q6INS5 557 62872 S453 Q V N R G K G S P D E Y E L R
Zebra Danio Brachydanio rerio Q7T308 474 53229 K381 E N S V D R R K G S A D S Y Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393681 789 90729 S671 I E M Q E R I S K N N N S T E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 22.5 76.5 N.A. 63.9 64 N.A. 29 43.4 39.7 34.3 N.A. N.A. 21.2 N.A. N.A.
Protein Similarity: 100 99.6 24.5 84.2 N.A. 75.3 74.9 N.A. 43.2 56.8 55.8 51.1 N.A. N.A. 41.1 N.A. N.A.
P-Site Identity: 100 100 20 86.6 N.A. 86.6 86.6 N.A. 0 80 73.3 0 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 100 100 46.6 86.6 N.A. 93.3 93.3 N.A. 13.3 86.6 73.3 20 N.A. N.A. 40 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 10 0 0 0 10 0 0 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 10 0 0 0 0 64 0 10 0 0 0 % D
% Glu: 10 19 0 10 19 0 0 0 10 10 55 10 10 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 10 0 64 0 10 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 0 % H
% Ile: 10 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % I
% Lys: 10 0 0 0 0 64 0 10 10 0 10 0 0 10 0 % K
% Leu: 10 10 0 0 0 0 10 10 0 0 0 0 10 64 0 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 64 0 0 0 0 0 0 10 10 10 10 0 0 % N
% Pro: 0 46 10 0 0 0 0 0 64 0 0 10 10 0 0 % P
% Gln: 10 0 0 10 55 0 0 0 0 0 19 0 28 0 10 % Q
% Arg: 0 0 0 64 10 28 10 0 10 0 0 0 0 0 64 % R
% Ser: 0 10 10 0 0 0 0 82 0 10 0 0 19 0 10 % S
% Thr: 0 0 0 0 0 0 0 0 0 10 0 0 0 10 0 % T
% Val: 46 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 0 0 0 0 64 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _